Simple steps for preparation and injection
STEP ONE: Prepare
Allow the product to reach room temp. 59-86° F before using.
STEP TWO: Assemble
Follow assembly instructions provided in Prescribing Information.
STEP THREE: Mix
Thoroughly mix the product for at least 45 seconds.
STEP FOUR: Administer
Inject Fensolvi® at a 90° angle into subcutaneous tissue.
Fensolvi is administered by a healthcare professional as a 45 mg single subcutaneous injection once every six months. 
Fensolvi is administered subcutaneously, where it forms a solid in situ, trapping the leuprolide acetate within the biodegradable polymer matrix. The polymeric gel dissolves over time, resulting in sustained and consistent release of leuprolide acetate over the six-month dosing period. 
As with other drugs administered by subcutaneous injection, the injection site should vary periodically. The most commonly used injection sites are buttocks and upper thighs.
The specific injection location should not have excessive pigment, nodules, lesions, or hair. Areas with brawny or fibrous subcutaneous tissue or locations that could be rubbed or compressed (i.e., by a belt or clothing waistband) should be avoided. 
Fensolvi is prefilled and supplied in two separate, sterile syringes whose contents are reconstituted.
Fensolvi must be brought to room temperature before mixing.
Once outside the refrigerator this product may be stored in its original packaging at room temperature 59 – 86 °F (15 – 30 °C) for up to eight weeks prior to mixing and administration.
Once mixed, the product must be administered within 30 minutes or it should be discarded.
- Fensolvi® (leuprolide acetate) for injectable suspension 45 mg Prescribing Information. Dublin 2, Ireland: Tolmar International, Ltd.; 04/2022.